Clinical Genetics Made Ridiculously Simple

The burgeoning field of Genetics is a complex and formidable topic for the student and practitioner. It is easy to get lost in the forest for the trees since genetics lends itself anywhere from a basic foundation of DNA and its parts, to a more complicated and nuanced understanding of how these parts work together, what happens when things go wrong, how to diagnose and treat genetic disorders, and the latest advances and areas of hope in genetic research.

Clinical Genetics Made Ridiculously Simple presents a way to rapidly visualize the field as a whole, including basic genetics, chromosomal abnormalities, epigenetic disorders, cancer, screening tests, gene sequencing, CRISPR, homeobox genes, and changing approaches to the clinical diagnosis and treatment of genetic conditions.

The author builds  from the basics of genetics and DNA, to an understanding of how our genetic material functions, what we presently know about genetic defects, and cutting edge solutions to these problems. Each topic is carefully taught, one step at a time, so that the student is never lost, all in 112 pages!

$24.95

Book Details

Pages

112

ISBN

9781935660439

Publication

September 15, 2020

Language

English

About The Author

Stephen  Goldberg

Stephen Goldberg, MD, a graduate of the Albert Einstein College of Medicine, trained in Neurology, Ophthalmology, and Family Medicine. He is a neurologic researcher, teacher, computer programmer, writer, editor, and president of the Medmaster publishing company. Dr. Goldberg has published numerous papers on neuronal development and regeneration through research at the Albert Einstein College of Medicine, National Institutes of Health, New York Medical College and the University of Miami. He is the author of the best-selling book, Clinical Neuroanatomy Made Ridiculously Simple, as well as the interactive computer program Neurologic Localization. As a coordinator of neuroanatomy education at the University of Miami Miller School of Medicine for 25 years, his reputation is that of an educator who can simplify complex topics. He received the George Paff Most Outstanding Professor Teaching Award 11 times at the U of M and was invited to be the keynote speaker at the medical school graduation commencement at the Washington University School of Medicine in St. Louis in 2004. He has also authored textbooks of Anatomy, Physiology, Biochemistry, Biostatistics, Neurology, Ophthalmology and Computer Programming, as well as many interactive computer programs on a variety of medical topics.

Table of Contents:

Introduction

Part I. Classic Genetics

Chapter 1. Mendelian Genetics
What Exactly Is a Gene?
Nomenclature

Chapter 2. Mitosis and Meiosis
Mitosis
Meiosis

Chapter 3. DNA Replication, Transcription, and Translation
Replication of DNA
   -Transposons
   -Tandem Repeats
Transcription of DNA into RNA
   -Introns
   -Transcription Factors
Translation of RNA into Proteins
   -Messenger, Transfer, and Ribosomal RNA
   -Protein Modification
   -Mitochondrial Inheritance

Part II. When Things Go Wrong

Chapter 4. Chromosomal Abnormalities
Too Many or Too Few Chromosomes
Translocation of Chromosome Segments
Inversion of Chromosome Segments
Duplications and Deletions of Chromosome Segments
DNA Point Mutations

Chapter 5. Epigenetic Disorders 

Chapter 6. Cancer
Inherited Cancer

Part III. Diagnosis and Treatment of Genetic Disorders

Chapter 7. History and Physical Exam
Pedigree Tree

Chapter 8. Laboratory
Should You Do Genetic Testing?
Indications for Referral and Cytogenetic Testing
Cytogenetic Screening Tests
Polymerase Chain Reaction (PCR)
Fluorescence In Situ Hybridization (FISH)
Next Generation Sequencing

Chapter 9. Treatment
CRISPR
Treatment of Cancer
   -Immunotherapy
Pharmacogenomics

Chapter 10. Homeobox Genes
Appendix. Diseases
Index